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KMID : 0364519940050020143
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Dong-A Journal Medicine
1994 Volume.5 No. 2 p.143 ~ p.148
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Prevalence of Anti-HCV among the Chronic Renal Failure Patients Treated with Hemodialysis
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Abstract
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Chronic renal failure patients have a high risk for infection because of decreased cellular immunity. Higher rate of positive anti-HCV in these patients has been noted. While several studies have made a consensus that duration of hemodialysis
plays
an
important role in acquisition of hepatitis C virus (HCV), there is some debate upon the contribution of transfusion. The author planned this study to assess the prevalence of anti-HCV in our hemodialysis unit and to estimate the role of
transfusion
and
duration of hemodialysis in acquisition of anti-HCV
Positive anti-HCV cases were 15/82(18.3%) at September 1992, 13/84(15.5%) at August 1993, and 10/74 (13.5%) at January 1994. The mean duration of hemodialysis in 19 positive anti-HCV cases and in 70 negative anti-HCV cases among total 89 patients
was
43.84±45.69 months and 18.24±21.48 months. 14 (73.6%) patients with anti-HCV and 15(30.0%) patients without anti-HCV had the history of transfusion before anti-HCV screening for the volunteer blood donor. But there was no difference between
these
two
groups in the history of transfusion after routine anti-HCV screening for the donor blood. 10 (52.6%) cases and 6 (8.6%) cases showed elevated alanine aminotransferase (ALT) level 2 times higher than normal value.
The author concluded that the acquisition of anti-HCV among chronic renal failure patients treated with hemodialysis is associated with longer duration of hemodialysis (p<0.01), history of transfusion before routine anti-HCV screening for the
donor
blood (p<0.005), and episode of elevation of in ALT level prior to HCV acquisition (p<0.05), which support the need for isolated hemodialysis for anti-HCV positive patients and frequent follow-up of serum ALT and anti-HCV in hemodialysis unit.
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KEYWORD
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